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cenobamate will improve the degree or effect of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely. Contemplate a dose reduction of CYP2C19 substrates, as clinically suitable, when utilized concomitantly with cenobamate.iloperidone raises amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabo